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Carrier-free Nanodrug-based Virus-Surface-Mimicking Nanosystems for Efficient Drug/Gene co-Delivery

Abstract

Nature-inspired nanoparticles, from pathogens to mammalian cells, have attracted increasing attention, for their specific functions and unparalled features that are often desired in designing drug/gene delivery nonviral vector. However, the applications of nonviral vectors are still suffering from the limits of the low drug loading efficiency and/or the low gene transfection efficiency. Herein, a novel carrier-free nanodrug-based virus-surface-mimicking gene delivery nanosystems are designed by condensing the doxorubicin nanoparticles (DNPs) onto the surface of the PEI/DNA nanocomplex through electrostatic force, which would prolong the blood circulation time of PEI/DNA and confer high drug loading characteristics to PEI/DNA nanosystem. Meanwhile, the gene transfection efficiency of DNA can also be enhanced for the increased roughness of coated DNPs. The in vitro and in vivo results demonstrate that the carrier-free nanodrug-based gene delivery nanosystems with high drug loading efficiency (97.5%) as well as a rough surface can enhance the endocytosis of the nanoparticles, and consequently enhance the chemo/gene co-therapy of the cancers. It is the first time to use soft materials to design virus-surface-mimicking nanocarriers, avoiding the side effects of inorganic materials caused by their non-degradable property. Importantly, our delicate design opens a new pathway to develop a nature-inspired nanoparticle for cancer synergistic therapy.

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Publication details

The article was received on 25 Aug 2018, accepted on 05 Oct 2018 and first published on 05 Oct 2018


Article type: Paper
DOI: 10.1039/C8BM01033A
Citation: Biomater. Sci., 2018, Accepted Manuscript
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    Carrier-free Nanodrug-based Virus-Surface-Mimicking Nanosystems for Efficient Drug/Gene co-Delivery

    X. Sun, M. Li, Y. Yang, H. Jia and W. Liu, Biomater. Sci., 2018, Accepted Manuscript , DOI: 10.1039/C8BM01033A

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