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Sericin hydrogels promote skin wound healing with effective regeneration of hair follicles and sebaceous glands after complete loss of epidermis and dermis

Abstract

Skin full-thickness injury affects millions of people each year worldwide. It often leads to scar formation and loss of appendages even after clinical treatment. The majority of wound dressings used so far could not achieve scarless skin regeneration with complete recovery of appendages, such as hair follicles and sebaceous glands. Functional regeneration of these skin appendages is of great challenge. However, we achieved this goal by the successful development and utilization of a photo-crosslinkable sericin hydrogel (SMH) as a new type of wound dressing for repairing skin full-thickness injury. SMH implanted in a mouse skin full-thickness injury model promotes scarless wound healing with effective regeneration of hair follicles and sebaceous glands. By employing techniques of molecular biology, biochemistry, and in vivo cell tracing, we revealed the underlying repair mechanisms: SMH inhibited inflammation, stimulated angiogenesis during healing process, prevented scar tissue formation via regulating the expression of TGF-β1 and TGF-β3, and recruited mesenchymal stem cells to injury sites for the regeneration of skin appendages. Collectively, this work developed a sericin based hydrogel as wound dressing for full-thickness skin injury repair, uncovered the functional roles of sericin hydrogels in promoting scarless skin regeneration along with effective recovery of skin appendages, and thus unveiled sericin’s potential for skin wound healing.

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Publication details

The article was received on 07 Aug 2018, accepted on 12 Sep 2018 and first published on 12 Sep 2018


Article type: Paper
DOI: 10.1039/C8BM00934A
Citation: Biomater. Sci., 2018, Accepted Manuscript
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    Sericin hydrogels promote skin wound healing with effective regeneration of hair follicles and sebaceous glands after complete loss of epidermis and dermis

    C. Qi, L. Xu, Y. Deng, G. Wang, Z. Wang and L. Wang, Biomater. Sci., 2018, Accepted Manuscript , DOI: 10.1039/C8BM00934A

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