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in situ release of endogenous cations from xenograft bone driven by fluoride incorporation contributes to enhanced bone regeneration

Abstract

Xenograft, namely bone-devired biological apatite (BAp), is widely recognized as a favorable biomaterial in bone tissue engineering owing to biodegradability, biocompatibility, and osteoconductive properties. Substitutions of endogenous trace ions are thought to improve osteogenic capacity of xenograft when compared with synthetic hydroxyapatite (HAp). In order to modify the physicochemical and biological properties of apatite, different approaches to induce trace ion incorporation have been widely considered. In this study, we demonstrate that the incorporation of fluoride ion into porcine bone-derived biological apatite (pBAp) contributes to altered crystal morphology of the apatite, sustained release of fluoride, and in situ release of endogenous trace ions (e.g., magnesium and calcium) into the peripheral tissue microenvironment. This ionic balanced perimaterial microenvironment not only leads to superior proliferation and osteogenic differentiation of rat bone mesenchymal stem cells (rBMSCs), but also accelerates new bone formation of the calvarial defect on a rat model via the activation of Wnt/β-catenin signaling. These promising observations may attribute to the controlled release of endogenous trace ions from xenograft to the peripheral tissue microenvironment driven by fluoride ion incorporation. Lastly, this study may provide a new insight to strengthen the osteogenicity of xenografts for clinical applications in the future.

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Publication details

The article was received on 01 Aug 2018, accepted on 07 Sep 2018 and first published on 11 Sep 2018


Article type: Paper
DOI: 10.1039/C8BM00910D
Citation: Biomater. Sci., 2018, Accepted Manuscript
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    in situ release of endogenous cations from xenograft bone driven by fluoride incorporation contributes to enhanced bone regeneration

    W. Qiao, R. Liu, Z. Li, X. Luo, B. Huang, Q. Liu, Z. Chen, J. K. H. Tsoi, R. Y. X. Su, K. M.C. Cheung, J. P. Matinlinna, K. Yeung and Z. Chen, Biomater. Sci., 2018, Accepted Manuscript , DOI: 10.1039/C8BM00910D

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