Jump to main content
Jump to site search


Unimicellar hyperstars as multi-antigen cancer nanovaccines displaying clustered epitopes of immunostimulating peptides

Author affiliations

Abstract

Unimicellar hyperstar macromolecular chimeras displaying multiple melanoma peptide antigens were prepared primarily via a combination of click chemistry and esterification reactions starting from a biodegradable hyperbranched polymer template. Solubilization of the hyperstars in aqueous solution afforded a multi-antigen unimicellar cancer nanovaccine of about 20 nm. The nanovaccine showed good biocompatibility and uptake by dendritic cells in vitro. An in vivo evaluation of the nanovaccine therapeutic efficacy against melanoma in mice implanted with B16OVA tumors revealed significantly greater T-cell recruitment and improved survival rates for mice treated with nanovaccine and adjuvant compared to non-treated mice.

Graphical abstract: Unimicellar hyperstars as multi-antigen cancer nanovaccines displaying clustered epitopes of immunostimulating peptides

Back to tab navigation

Supplementary files

Publication details

The article was received on 29 Jul 2018, accepted on 05 Sep 2018 and first published on 11 Sep 2018


Article type: Communication
DOI: 10.1039/C8BM00891D
Citation: Biomater. Sci., 2018, Advance Article
  •   Request permissions

    Unimicellar hyperstars as multi-antigen cancer nanovaccines displaying clustered epitopes of immunostimulating peptides

    H. Kakwere, E. S. Ingham, R. Allen, L. M. Mahakian, S. M. Tam, H. Zhang, M. T. Silvestrini, J. S. Lewis and K. W. Ferrara, Biomater. Sci., 2018, Advance Article , DOI: 10.1039/C8BM00891D

Search articles by author

Spotlight

Advertisements