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Assembled anti-adhesion polypropylene mesh with self-fixable and degradable in situ mussel-inspired hydrogel coating for abdominal wall defect repair

Abstract

Abdominal adhesion with polypropylene (PP) mesh is still one of the main complications in hernia repair. Thus, it is still a great challenge how to endow the PP mesh with an excellent anti-adhesion property in hernia repair. Herein, in order to effectively improve anti-adhesive properties of PP mesh, the assembled polypropylene (PP) mesh with excellent anti-adhesion efficiency was developed through in situ coating PP mesh surface with self-fixable and biodegradable mussel-inspired hydrogels. Through mixing directly oxide-carboxymethylcellulose (OCMC) functionalized with dopamine (OCMC-DA) and carboxymethylchitosan (CMCS), biodegradable hydrogels (OCMC-DA/CMCS) layer can be formed in situ on PP mesh without addition of any crosslinking agents, in which dopamine acted as immobilization groups to fix hydrogels on PP mesh and tissue surface. Therefore the assembled PP mesh (OCMC-DA/CMCS/PP) was obtained. The properties of OCMC-DA/CMCS hydrogels was optimized, and OCMC-DA4/CMCS hydrogel was selected to construct the assembled PP mesh. The lap-shear test revealed that it has a property of tissue adhesion. In vitro cell testing proved the superior biocompatibility of hydrogel. A modulated bioabsorpation time and excellent anti-adhesion property was presented at in vivo test of rat abdominal wall defect model. Compared the native PP mesh group, the adhesion area and tenacity of the OCMC-DA4/CMCS/PP group decreased by more than 80 % with a slightly inflammation reaction.

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Publication details

The article was received on 18 Jul 2018, accepted on 12 Sep 2018 and first published on 14 Sep 2018


Article type: Paper
DOI: 10.1039/C8BM00824H
Citation: Biomater. Sci., 2018, Accepted Manuscript
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    Assembled anti-adhesion polypropylene mesh with self-fixable and degradable in situ mussel-inspired hydrogel coating for abdominal wall defect repair

    W. Hu, Z. zhang, S. Lu, T. Zhang, N. Zhou, P. Ren, F. Wang, Y. Yang and Z. Ji, Biomater. Sci., 2018, Accepted Manuscript , DOI: 10.1039/C8BM00824H

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