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Thermosensitive Drug-loading System Based on Copper Sulfide Nanoparticles for Combined Photothermal Therapy and Chemotherapy In Vivo

Abstract

Phase change material (PCM) is an efficient energy storage material while its poor thermal conductivity has limited its application. In this study, we use the photothermal material copper sulfide (CuS) to tackle this challenge. The designed CuS-DOX-MBA@PCM nanoparticles (NPs) were prepared by nanoprecipitation method, which are composed of CuS, anticancer drug (DOX) and near-infrared (NIR) dyes (MBA) encapsulated with stearic acid and lauric acid that are characterized by low eutectic point closed to human physiological temperature. Because the CuS-DOX-MBA@PCM NPs can release the drug quickly in physiological conditions, it can be credited as a promising drug loading system. CuS-DOX-MBA@PCM NPs were utilized as an imaging-guided photothermal agent for photothermal therapy (PTT) combined with chemotherapy in cells and in a mice model. In vitro fluorescence imaging indicated the high uptake of CuS-DOX-MBA@PCM NPs in tumor cells due to enhanced permeability and retention effects, and in vivo experiments showed that tumor growth in tumor-bearing mice models could be inhibited by CuS-DOX-MBA@PCM NPs. Results in this study confirmed the clinical value of the designed thermosensitive drug-loading system in the field of cancer therapy.

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Publication details

The article was received on 12 Jul 2018, accepted on 10 Sep 2018 and first published on 13 Sep 2018


Article type: Paper
DOI: 10.1039/C8BM00799C
Citation: Biomater. Sci., 2018, Accepted Manuscript
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    Thermosensitive Drug-loading System Based on Copper Sulfide Nanoparticles for Combined Photothermal Therapy and Chemotherapy In Vivo

    Z. Yuan, S. Qu, Y. He, L. Liang, X. Zhou, L. Gui, Y. Xu, Y. Gu and H. Chen, Biomater. Sci., 2018, Accepted Manuscript , DOI: 10.1039/C8BM00799C

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