Jump to main content
Jump to site search


Non-triggered sequentially-released liposomes enhance anti-breast cancer efficacy of STS and celastrol-based microemulsion

Abstract

Sequentially-released codelivery system is an effective strategy to enhance anticancer efficacy. Here, we fabricate multicomponent-based liposomes (T/CM-L) loaded with sodium tanshinone IIA sulfonate (STS) and small-sized microemulsion of celastrol (CM), which shows synergistic anti-breast cancer activity through initial release of STS for modulation of tumor microenvironment and subsequent release of CM (and its payloads) for eradication of tumor tissues. In vitro studies exhibited that T/CM-L induced massive apoptosis toward MCF-7 cells, indicating coordinated cytotoxicity against cancer cells. Once liposomes accumulated at the tumor site, STS was released from T/CM-L in the first place to repair abnormal vessels as well as decrease fibroblasts. Owing to the retardarce by barriers of microemulsion and liposome, celastrol was then unloaded moderately to kill tumor cells, resulting in shrink of tumor size. Furthermore, T/CM-L displayed diminished systemic toxicity compared to celastrol used alone. Our work offers a novel strategy for combination anticancer treatment and holds promising potential not only in breast cancer treatment, but also in other solid tumors.

Back to tab navigation

Supplementary files

Publication details

The article was received on 12 Jul 2018, accepted on 28 Sep 2018 and first published on 05 Oct 2018


Article type: Paper
DOI: 10.1039/C8BM00796A
Citation: Biomater. Sci., 2018, Accepted Manuscript
  •   Request permissions

    Non-triggered sequentially-released liposomes enhance anti-breast cancer efficacy of STS and celastrol-based microemulsion

    D. Qu, L. Wang, Y. Qin, M. Guo, J. Guo, M. Huang, Y. Liu, C. Liu, H. li and Y. Chen, Biomater. Sci., 2018, Accepted Manuscript , DOI: 10.1039/C8BM00796A

Search articles by author

Spotlight

Advertisements