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Issue 10, 2018
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A comparative study of dissolving hyaluronic acid microneedles with trehalose and poly(vinyl pyrrolidone) for efficient peptide drug delivery

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Abstract

We studied the role of the additives trehalose and poly(vinyl pyrrolidone) in the physical and pharmacokinetic properties of peptide drug incorporated hyaluronic acid microneedles. Poly(vinyl pyrrolidone) increases the mechanical strength of microneedles and ameliorates drug bioavailability in vivo, suggesting that poly(vinyl pyrrolidone) can be a promising additive in the fabrication of peptide drug-encapsulated fully dissolving microneedles.

Graphical abstract: A comparative study of dissolving hyaluronic acid microneedles with trehalose and poly(vinyl pyrrolidone) for efficient peptide drug delivery

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Publication details

The article was received on 06 Jul 2018, accepted on 28 Jul 2018 and first published on 07 Aug 2018


Article type: Communication
DOI: 10.1039/C8BM00768C
Citation: Biomater. Sci., 2018,6, 2566-2570
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    A comparative study of dissolving hyaluronic acid microneedles with trehalose and poly(vinyl pyrrolidone) for efficient peptide drug delivery

    H. K. Kim, S. H. Lee, B. Y. Lee, S. J. Kim, C. Y. Sung, N. K. Jang, J. D. Kim, D. H. Jeong, H. Y. Ryu and S. Lee, Biomater. Sci., 2018, 6, 2566
    DOI: 10.1039/C8BM00768C

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