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Ultrasmall hybrid protein-copper sulfide nanoparticles for targeted photoacoustic imaging of orthotopic hepatocellular carcinoma with high signal-to-noise ratio

Abstract

Although photoacoustic imaging combined with second near infrared (NIR II) molecular probes for tumor diagnosis has drawn tremendous attention during the last decades, the targeted photoacousctic imaging of orthotopic hepatocellular carcinoma (HCC) is still challenging due to the high liver vascularization and non-specificity of probes in liver tumors. Herein, we report cyclic arginine-glycine-aspartic acid (cRGD) peptides conjugated ultrasmall CuS nanoparticles (CuS@BSA-RGD NPs) which encapsulate bovine serum albumin (BSA) and possess high optical absorption at 1064 nm. The Encapsulation of BSA results in great biocompatibility of CuS@BSA-RGD NPs along with excellent photostability and physiological stability. The cRGD conjugation enables the improvement of tumor uptake of CuS@BSA-RGD NPs in virtue of its positive tumor cell targeting capability. The efficient accumulation of CuS@BSA-RGD NPs in the tumor over time after intravenous administration to orthotopic HCC bearing mice achieved, resulting in highly sensitive photoacoustic visualization of the tumor region. Toxicity study indicates that CuS@BSA-RGD NPs exhibited negligible systemic toxicity in vivo. The results demonstrate that the CuS@BSA-RGD NPs might hold great promise for the future imaging and diagnosis of cancer.

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Publication details

The article was received on 06 Jul 2018, accepted on 05 Oct 2018 and first published on 10 Oct 2018


Article type: Paper
DOI: 10.1039/C8BM00767E
Citation: Biomater. Sci., 2018, Accepted Manuscript
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    Ultrasmall hybrid protein-copper sulfide nanoparticles for targeted photoacoustic imaging of orthotopic hepatocellular carcinoma with high signal-to-noise ratio

    H. Yan, J. Chen, Y. Li, Y. Bai, Y. Wu, Z. Sheng, L. Song, C. Liu and H. Zhang, Biomater. Sci., 2018, Accepted Manuscript , DOI: 10.1039/C8BM00767E

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