Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 10, 2018
Previous Article Next Article

Facile synthesis and surface modification of bioinspired nanoparticles from quercetin for drug delivery

Author affiliations

Abstract

Nanoparticle-mediated drug delivery has demonstrated great potential to treat various diseases especially cancer. However, there is an unmet need for the scalable synthesis of multifunctional nanoparticles to meet the complex challenges of drug delivery. Here we show that we can synthesize nanoparticles from the polyphenol quercetin, which can be conveniently functionalized with ligands and drug molecules by simple mixing under ambient conditions. Nanoparticles (∼30–40 nm in diameter) were formed by oxidative self-polymerization of quercetin in alkaline buffer (pH 9). The reactivity of oxidized polyphenols was exploited to immobilize amine-terminated methoxy poly(ethylene glycol) on the nanoparticles’ surface for steric stability, followed by loading with doxorubicin as a model drug. Surface modification of the nanoparticles was confirmed by X-ray Photoelectron Spectroscopy. An antioxidant assay showed that the nanoparticles retained some antioxidant activity. The nanoparticles were readily internalized by KB cells via an endo-lysosomal pathway. Doxorubicin-loaded nanoparticles showed a drug loading of 35.6 ± 4.9% w/w with a loading efficiency of 88.9 ± 12.4%, sustained drug release, and potent cytotoxicity in vitro. Our findings demonstrate a promising new application for naturally occurring polyphenols as a renewable source of drug delivery nanocarriers that can be synthesized at low cost with minimal equipment.

Graphical abstract: Facile synthesis and surface modification of bioinspired nanoparticles from quercetin for drug delivery

Back to tab navigation

Supplementary files

Article information


Submitted
28 May 2018
Accepted
20 Aug 2018
First published
20 Aug 2018

Biomater. Sci., 2018,6, 2656-2666
Article type
Paper

Facile synthesis and surface modification of bioinspired nanoparticles from quercetin for drug delivery

S. Sunoqrot, E. Al-Shalabi and P. B. Messersmith, Biomater. Sci., 2018, 6, 2656
DOI: 10.1039/C8BM00587G

Social activity

Search articles by author

Spotlight

Advertisements