Jump to main content
Jump to site search

Issue 7, 2018

Highly reactive crystalline-phase-embedded strontium-bioactive nanorods for multimodal bioactive applications

Author affiliations

Abstract

In the present work, a crystallization-induced strontium-bioactive material, with a composition similar to Bioglass 45S5 system, was obtained using a sol–gel-assisted microwave method with nanorod morphologies of 30–80 nm in size. The effect of crystallization induced in the glass network, and its influence on the bioactivity and mechanical properties of bone and dentin regeneration, were the main novel findings of this work. Rietveld analysis of X-ray diffraction spectra showed the best fit with sodium (combeite, Na2Ca2Si3O9) and calcium (clinophosinaite, Ca2Na6O14P2Si2; calcium strontium silicate, Ca1.5O4SiSr0.5; and calcium carbonate, CaCO3) enriched crystal systems. Multinuclear solid-state NMR studies provided detailed atomistic insight into the presence of crystalline mineral phases in the bioactive material. The dentin matrix and antibacterial studies showed good results for 5% strontium-substituted calcium compared with basic 45S5 composition due to its smaller particle size (30 nm), which suggested applications to dentin regeneration. Simulation studies have been demonstrated with clinophosinaite crystal data from the XRD spectra, with the glycoprotein salivary metabolites also showing that 5% strontium-substituted calcium has a higher binding affinity for the salivary compound, which is suitable for dentin regeneration applications. In vitro apatite formation studies showed that this material is suitable for bone regeneration applications.

Graphical abstract: Highly reactive crystalline-phase-embedded strontium-bioactive nanorods for multimodal bioactive applications

Supplementary files

Article information


Submitted
28 Mar 2018
Accepted
14 May 2018
First published
15 May 2018

Biomater. Sci., 2018,6, 1764-1776
Article type
Paper

Highly reactive crystalline-phase-embedded strontium-bioactive nanorods for multimodal bioactive applications

D. Durgalakshmi, R. Ajay Rakkesh, M. Kesavan, S. Ganapathy, T. G. Ajithkumar, S. Karthikeyan and S. Balakumar, Biomater. Sci., 2018, 6, 1764 DOI: 10.1039/C8BM00362A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.


Social activity

Search articles by author

Spotlight

Advertisements