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Pyrrole-containing hydrazone and its resultant Cu2+ complex: an easily accessible optical chemosensor system for the successive detection of Zn2+/Cu2+ and pyrophosphate

Abstract

A simple chemosensor, namely, ethyl 5-(isonicotinoylimino)methyl-2,4-dimethyl-pyrrole-3-carboxylate (1), was synthesized and characterized. Probe 1 exhibited great selectivity when used as an off-on fluorescence sensor for Zn2+. Moreover, 1 can be used as colorimetric probe for the detection of Cu2+ in semiaqueous media. The putative binding mechanism of 1 with its target analytes was confirmed through UV–Vis absorption analysis, fluorescence measurements, mass spectroscopy, 1H NMR analysis, and density functional theory calculations. In addition, the resulting 1+Cu2+ complex can be used as a colorimetric sensor for pyrophosphate. Probe 1 is successfully applied in monitoring intracellular Zn2+ in the glioma cell line U251.

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Publication details

The article was received on 11 Sep 2018, accepted on 04 Nov 2018 and first published on 06 Nov 2018


Article type: Paper
DOI: 10.1039/C8AY01993B
Citation: Anal. Methods, 2018, Accepted Manuscript
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    Pyrrole-containing hydrazone and its resultant Cu2+ complex: an easily accessible optical chemosensor system for the successive detection of Zn2+/Cu2+ and pyrophosphate

    Y. Wang, X. Hou, Z. Li, M. Lei, Q. Zhou, S. Hu, X. Wu, C. Li, Z. Xu and Y. Wang, Anal. Methods, 2018, Accepted Manuscript , DOI: 10.1039/C8AY01993B

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