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A highly sensitive SERS probe for bisphenol A detection based on functionalized Au@Ag nanoparticles

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Abstract

Bisphenol A (BPA) usually exists in daily plastic products and its harmful effect on human health has been a popular topic. However, many conventional analytical methods need long sample preparation and measurement time, and some BPA biosensors suffer from the limitation of complex probe modification. Herein, we designed a simple SERS-coded aptamer sensor for BPA detection based on the electrostatic interaction between chitosan encapsulated 4-MBA coated Au@Ag NPs and anti-BPA aptamers. The negatively charged nucleic acid anti-BPA aptamer will cause the aggregation of the positively charged noble metal nano-reinforced substrate in acid buffer systems, resulting in a significant enhancement of the Raman signal. The specific binding of BPA with nucleic acid anti-BPA aptamers reduced the degree of aggregation of nanoparticles and weakened the SERS signal. This SERS-coded aptamer sensor had a wide linear range of 0.01–1 ng mL−1 and the limit of detection (LOD) was as low as 2.8 pg mL−1, and the method was successfully applied to detect BPA in bottled water within 15 min. As a rapid, simple, ultrasensitive and highly selective analytical technique for the detection of BPA, this SERS-based method would be important in biomedical diagnostics, environmental monitoring and food safety.

Graphical abstract: A highly sensitive SERS probe for bisphenol A detection based on functionalized Au@Ag nanoparticles

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Publication details

The article was received on 08 Sep 2018, accepted on 23 Oct 2018 and first published on 24 Oct 2018


Article type: Paper
DOI: 10.1039/C8AY01966E
Citation: Anal. Methods, 2018, Advance Article
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    A highly sensitive SERS probe for bisphenol A detection based on functionalized Au@Ag nanoparticles

    C. Wang, Y. Zeng, A. Shen and J. Hu, Anal. Methods, 2018, Advance Article , DOI: 10.1039/C8AY01966E

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