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Sensitive determination of psoralen and isopsoralen in Fructus Psoraleae by online solid phase microextraction with porphyrin-based porous organic polymers modified on capillary

Abstract

Novel porphyrin based porous organic polymers modified capillary (PPOPs-capillary) was prepared for extraction of psoralen and isopsoralen in Fructus Psoraleae. Fructus Psoraleae is an important traditional Chinese medicine in clinical therapy. Sensitive and effective extraction and determination of psoralen and isopsoralen benefit the quality control in Fructus Psoraleae and related preparations. The PPOPs were immobilized on the inner wall of capillary by a bottom-up approach. The formation of PPOPs has been confirmed by scanning electron microscopy (SEM), X-ray diffraction (XRD) and Fourier transform infrared spectra (FT-IR). An online solid phase microextraction coupled with HPLC method was developed for selective extraction and analysis of psoralen and isopsoralen in aqueous solutions. The proposed method showed a good linear range of 0.05-100 ng/mL with a low limit of detection of 0.01 ng/mL. The method was also applied for the extraction of psoralen and isopsoralen in Fructus Psoraleae, which showed high enrichment efficiency and good clean-up capacity. Recoveries were calculated to be 93.3-96.7% with relative standard deviations less than 1.6%.

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Publication details

The article was received on 26 Aug 2018, accepted on 27 Oct 2018 and first published on 01 Nov 2018


Article type: Paper
DOI: 10.1039/C8AY01885E
Citation: Anal. Methods, 2018, Accepted Manuscript
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    Sensitive determination of psoralen and isopsoralen in Fructus Psoraleae by online solid phase microextraction with porphyrin-based porous organic polymers modified on capillary

    Y. Chen, R. Wang and Z. Chen, Anal. Methods, 2018, Accepted Manuscript , DOI: 10.1039/C8AY01885E

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