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Engineering MOF-magnetic graphene oxide nanocomposite for enantioselective capture

Abstract

A novel magnetic graphene oxide-metal organic framework [Zn2(BTC)(NO3)(DMA)3]n (MGO-ZnBND) possessing of both magnetic property and excellent enantioselective capture of chiral drug intermediates was prepared and characterized in this paper. The MGO-ZnBND nanocomposite combines the superior properties of each component, makes up for the defects of the application of single component and shows more excellent physicochemical properties. Solutions of racemic 2, 2ʹ-furoin and benzoin were chosen to investigate the enantioselective performance of MGO-ZnBND nanocomposite by dispersive magnetic nanoparticle solid phase extraction (d-MNSPE). Under the optimized conditions, the nanocomposite has excellent enantioselectivity to 2, 2ʹ-furoin and benzoin with enantiomeric excess (ee) values reaching up to 85% and 66%. The entire process with 2, 2ʹ-furoin and benzoin can be completed within 4 min and 6 min, respectively. After washed with methanol, the host MGO-ZnBND can be easily recycled and reused six times without any apparent loss of performance.

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Publication details

The article was received on 24 Aug 2018, accepted on 06 Nov 2018 and first published on 08 Nov 2018


Article type: Paper
DOI: 10.1039/C8AY01876F
Citation: Anal. Methods, 2018, Accepted Manuscript
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    Engineering MOF-magnetic graphene oxide nanocomposite for enantioselective capture

    Y. Gao, W. Du, A. Yu, X. Li, W. Zhao and S. Zhang, Anal. Methods, 2018, Accepted Manuscript , DOI: 10.1039/C8AY01876F

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