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A CoOOH nanoflake-based light scattering probe for the simple and selective detection of uric acid in human serum

Abstract

As a primary metabolic product of purine nucleotides, uric acid (UA) usually presents in urine and serum, which is closely related to human health. With the catalysis of uricase, uric acid can yield allantoin, CO2 and H2O2. Then, the produced H2O2 was able to decompose CoOOH nanoflakes into Co2+, resulting in the smaller size with the weakened light scattering. This work provides a simple and selective light scattering method for UA analysis with a linear range from 1.0×10-5 to 1.0×10-3 M and detection limit of 1.0×10-6 M. In addition, this method has been successfully applied to the determination of UA in human serum samples with the similar results to the clinical methods.

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Publication details

The article was received on 19 Aug 2018, accepted on 11 Sep 2018 and first published on 12 Sep 2018


Article type: Paper
DOI: 10.1039/C8AY01839A
Citation: Anal. Methods, 2018, Accepted Manuscript
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    A CoOOH nanoflake-based light scattering probe for the simple and selective detection of uric acid in human serum

    Z. Y. Mao, L. N. Zhu, J. Gao, J. J. Liu, Y. H. Wei, X. Y. Li, B. Yin and J. Wang, Anal. Methods, 2018, Accepted Manuscript , DOI: 10.1039/C8AY01839A

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