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Issue 40, 2018
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A CoOOH nanoflake-based light scattering probe for the simple and selective detection of uric acid in human serum

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Abstract

As a major metabolic product of purine nucleotides, uric acid (UA) usually presents in urine and serum, which is closely related to human health. With the catalysis by uricase, uric acid can yield allantoin, CO2 and H2O2. Then, the produced H2O2 is able to decompose CoOOH nanoflakes into Co2+, resulting in a smaller size with weakened light scattering. This work provides a simple and selective light scattering method for UA analysis with a linear range from 1.0 × 10−5 to 1.0 × 10−3 M and a detection limit of 1.0 × 10−6 M. In addition, this method has been successfully applied to the determination of UA in human serum samples with similar results to clinical methods.

Graphical abstract: A CoOOH nanoflake-based light scattering probe for the simple and selective detection of uric acid in human serum

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Publication details

The article was received on 19 Aug 2018, accepted on 11 Sep 2018 and first published on 12 Sep 2018


Article type: Paper
DOI: 10.1039/C8AY01839A
Citation: Anal. Methods, 2018,10, 4951-4957
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    A CoOOH nanoflake-based light scattering probe for the simple and selective detection of uric acid in human serum

    Z. Y. Mao, L. N. Zhu, J. Gao, J. J. Liu, Y. H. Wei, X. Y. Li, B. C. Yin and J. Wang, Anal. Methods, 2018, 10, 4951
    DOI: 10.1039/C8AY01839A

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