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Issue 46, 2018
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Triglyceride and high density lipoprotein cholesterol concentrations quantitative analysis in whole blood by FTIR-ATR spectroscopy and FT-Raman spectroscopy

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Abstract

The triglyceride (TG) to high density lipoprotein cholesterol ratio (TG/HDL-C) and the TG level itself have both been identified as a biomarker of insulin resistance, cardiovascular disease and a predictor for atherosclerosis. The aim of this study is to evaluate the feasibility of spectroscopy combined with partial least squares regression for quantitative analysis of TG and HDL-C in whole blood samples. Comparison of quantitative analysis results based on Fourier transform infrared spectra and Raman spectra was performed. The experimental results on whole blood samples demonstrate that the multi-component blood lipid quantitative analysis model based on FTIR-ATR spectroscopy has superior performance, and it is feasible to apply FTIR-ATR spectroscopy in point-of-care diagnostics of complex bio-fluids.

Graphical abstract: Triglyceride and high density lipoprotein cholesterol concentrations quantitative analysis in whole blood by FTIR-ATR spectroscopy and FT-Raman spectroscopy

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Publication details

The article was received on 20 Jul 2018, accepted on 02 Oct 2018 and first published on 03 Oct 2018


Article type: Paper
DOI: 10.1039/C8AY01620H
Citation: Anal. Methods, 2018,10, 5493-5498
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    Triglyceride and high density lipoprotein cholesterol concentrations quantitative analysis in whole blood by FTIR-ATR spectroscopy and FT-Raman spectroscopy

    Z. Li, X. Lan, X. Jiang, Q. Wang, Z. Ma and Z. He, Anal. Methods, 2018, 10, 5493
    DOI: 10.1039/C8AY01620H

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