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Cu2+ modulated DNA-templated silver nanoclusters as a turn-on fluorescence probe for the detection of quinolones

Abstract

In this contribution, DNA-templated silver nanoclusters (DNA-AgNCs) as novel fluorescent probes were successfully utilized for the detection of quinolones for the first time. The as-prepared DNA-AgNCs exhibited strong emission at 596 nm, which could be quenched by Cu2+ ions. The addition of quinolones would cause the restoration of fluorescence intensity of the DNA-AgNCs-Cu2+ system. This detection protocol exhibited excellent sensitivities for four kinds of quinolones. For instance, the linear ranges were from 20 to 100 nM for nalidixic acid with the limit of detection (LOD) 2.0 nM, from 5 to 120 nM for cinoxacin with the LOD 1.2 nM, from 5 to 100 nM for ciprofloxacin with the LOD 1.0 nM, from 1 to 60 nM for moxifloxacin with the LOD 96 pM, respectively. Benefiting from the high sensitivity, the satisfactory recoveries were obtained for trace detection of quinolones in real samples, such as tablets and human urine.

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Publication details

The article was received on 06 Jul 2018, accepted on 03 Aug 2018 and first published on 06 Aug 2018


Article type: Paper
DOI: 10.1039/C8AY01497C
Citation: Anal. Methods, 2018, Accepted Manuscript
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    Cu2+ modulated DNA-templated silver nanoclusters as a turn-on fluorescence probe for the detection of quinolones

    R. Wang, X. Yan, J. Sun, X. Wang, X. Zhao, W. Liu and S. Zhu, Anal. Methods, 2018, Accepted Manuscript , DOI: 10.1039/C8AY01497C

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