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Issue 30, 2018
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Near-infrared and lysosome-targetable fluorescent probe based on phenoxazinium for hydrogen peroxide detection

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Abstract

A new near-infrared and lysosome-targetable fluorescent probe based on phenoxazinium was designed and prepared for hydrogen peroxide detection. This probe used phenoxazinium as the fluorophore acceptor and a methyl(phenyl)sulfane unit as the recognition group through a photoinduced electron transfer mechanism. With the addition of H2O2, the methyl(phenyl)sulfane unit of the probe was oxidized to a sulfoxide unit, causing enhanced fluorescence intensity at 676 nm due to the inhibition of photoinduced electron transfer. This probe not only showed competitive sensitivity, good selectivity, and a relatively fast response time, but also selectively targeted lysosomes of HeLa cells, indicating that it could be applied to detecting and visualizing H2O2 in HeLa cell lysosomes.

Graphical abstract: Near-infrared and lysosome-targetable fluorescent probe based on phenoxazinium for hydrogen peroxide detection

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Publication details

The article was received on 25 Jun 2018, accepted on 12 Jul 2018 and first published on 12 Jul 2018


Article type: Paper
DOI: 10.1039/C8AY01403E
Citation: Anal. Methods, 2018,10, 3754-3758
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    Near-infrared and lysosome-targetable fluorescent probe based on phenoxazinium for hydrogen peroxide detection

    Y. Chen, W. Zhu, X. Wei, Y. Xu, R. Sun and J. Ge, Anal. Methods, 2018, 10, 3754
    DOI: 10.1039/C8AY01403E

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