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Near-infrared and lysosome-targetable fluorescent probe based on phenoxazinium for detection of hydrogen peroxide

Abstract

A new near-infrared and lysosome-targetable fluorescent probe 2 based on phenoxazinium was designed and prepared for detection of hydrogen peroxide. This probe used phenoxazinium as fluorophore acceptor and methyl(phenyl)sulfane unit as the recognition group by photoinduced electron transfer mechanism. When addition of H2O2, Probe 2 bearing methyl(phenyl)sulfane unit was oxidized and turned into sulfoxide unit, the fluorescence intnesity will obviously be enhanced at 675 nm due to the inhibition of photoinduced electron transfer. In addition, probe 2 not only showed competitive sensitivity, good selectivity and relatively fast response time, but also could selectively targeted lysosomes of HeLa cells, and could be applied for detecting and visualizing H2O2 in the lysosomes of HeLa cells.

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Publication details

The article was received on 25 Jun 2018, accepted on 12 Jul 2018 and first published on 12 Jul 2018


Article type: Paper
DOI: 10.1039/C8AY01403E
Citation: Anal. Methods, 2018, Accepted Manuscript
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    Near-infrared and lysosome-targetable fluorescent probe based on phenoxazinium for detection of hydrogen peroxide

    Y. Chen, W. Zhu, X. Wei, Y. Xu, R. Sun and J. Ge, Anal. Methods, 2018, Accepted Manuscript , DOI: 10.1039/C8AY01403E

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