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A novel near-infrared probe for the imaging of superoxide anion fluctuations and hydrogen ion enhancement in vivo

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Abstract

Superoxide anions (O2˙) and hydrogen ions (H+) have attracted considerable attention in studies on cellular dysfunction. A newly synthesized reaction-based near-infrared imaging probe (IR-747-SAPH), which is composed of a superoxide anion responsive group and a H+ responsive group, exhibits high selectivity to O2˙ and H+ fluxes in vivo. The fluorescence intensity of IR-747-SAPH changes as O2˙ and H+ concentrations vary. IR-747-SAPH is characterized by sensitivity to changes in H+, high photostability, and strong near-infrared properties, including high temporal resolution, deep penetration, and low background interference. The probe also provides reliable near-infrared fluorescence signals that alter O2˙and H+ levels in vivo. Therefore, IR-747-SAPH fluorescence imaging is a promising detection method for monitoring the changes in O2˙ and H+ in various biological environments.

Graphical abstract: A novel near-infrared probe for the imaging of superoxide anion fluctuations and hydrogen ion enhancement in vivo

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Publication details

The article was received on 25 May 2018, accepted on 29 Jun 2018 and first published on 03 Jul 2018


Article type: Paper
DOI: 10.1039/C8AY01190G
Citation: Anal. Methods, 2018, Advance Article
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    A novel near-infrared probe for the imaging of superoxide anion fluctuations and hydrogen ion enhancement in vivo

    C. Sun, W. Du, W. Zhang, Y. Wu, Z. Yao, B. Wang, T. Wu, H. Yang, Y. Wang and L. Ren, Anal. Methods, 2018, Advance Article , DOI: 10.1039/C8AY01190G

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