Reaction-based fluorescent probes for rapid detection of hydrogen sulfide in vivo

Abstract

In this work, a series of novel fluorescent probes based on the fluorophores 3-benzothiazolyl-7-hydroxycoumarin/7-hydroxycoumarin were developed for detection of H₂S. The probes exhibited excellent specific responses to H₂S over other related competing species, including reactive sulfur, nitrogen and oxygen species. Moreover, the further successful imaging of the targetable fluorescent probe for sensing H₂S in vivo was exciting and revealed that this targetable probe could serve as an efficient tool to study H₂S-related chemical biology in physiological and pathological events.