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Identification of Proteins and Bacteria Based on Metal Ions-Gold Nanoclusters Sensor Array

Abstract

We report a simple fluorescence sensor array based on metal ions-gold nanoclusters (AuNCs) for the identification of proteins and bacteria. In this study, three protein-stabilized AuNCs including BSA-AuNCs, HSA-AuNCs and Lys-AuNCs were firstly synthesized. After the purification of these AuNCs by Zn2+ and Cd2+ respectively, six types of metal ions-AuNCs were employed as the sensing elements to fabricate a fluorescence sensor array. In presence of protein, differential changes of fluorescence intensity on sensing elements generate a unique response pattern for protein. Combining with linear discriminant analysis (LDA), 9 proteins with different concentrations were differentiated successfully. Moreover, 5 different bacteria were also be identified by the proposed sensor array. The method is simple, rapid, and sensitive and shows the potential applications in biomolecules sensing.

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Publication details

The article was received on 16 Mar 2018, accepted on 06 Jul 2018 and first published on 09 Jul 2018


Article type: Paper
DOI: 10.1039/C8AY00558C
Citation: Anal. Methods, 2018, Accepted Manuscript
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    Identification of Proteins and Bacteria Based on Metal Ions-Gold Nanoclusters Sensor Array

    Y. Wu, B. Wang, K. Wang and P. Yan, Anal. Methods, 2018, Accepted Manuscript , DOI: 10.1039/C8AY00558C

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