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Issue 9, 2018
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Effect of mobile phase composition on the analysis of aggregates of antibody drug conjugates (ADCs) using size exclusion chromatography

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Abstract

In this study, the effect of mobile phase composition for size exclusion chromatography (SEC) on antibody drug conjugate (ADC) aggregate analysis was investigated. The use of organic components as well as high ionic strength during aggregate analysis was demonstrated to be advantageous.

Graphical abstract: Effect of mobile phase composition on the analysis of aggregates of antibody drug conjugates (ADCs) using size exclusion chromatography

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Article information


Submitted
21 Nov 2017
Accepted
13 Dec 2017
First published
14 Dec 2017

Anal. Methods, 2018,10, 938-941
Article type
Communication

Effect of mobile phase composition on the analysis of aggregates of antibody drug conjugates (ADCs) using size exclusion chromatography

R. Neupane, M. Källsten, F. Lehmann and J. Bergquist, Anal. Methods, 2018, 10, 938
DOI: 10.1039/C7AY02696J

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