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A DNA Minimachine for Selective and Sensitive Detection of DNA

Abstract

Synthetic molecular machines have been explored to manipulate matter at the molecular level. Here we designed a multifunctional DNA nano-construct, dubbed ‘DNA minimachine’ (DMM) that (i) tightly binds complementary DNA; (ii) recognizes specific fragment with high selectivity and (iii) amplifies output signal. DMM1 detects lower concentrations of both single stranded DNA and double stranded DNA than a conventional probe. This study sets a direction towards development of molecular machines for selective, sensitive and cost-efficient DNA analysis.

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Publication details

The article was received on 23 Nov 2018, accepted on 05 Dec 2018 and first published on 07 Dec 2018


Article type: Communication
DOI: 10.1039/C8AN02274G
Citation: Analyst, 2018, Accepted Manuscript
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    A DNA Minimachine for Selective and Sensitive Detection of DNA

    T. Lyalina, E. A. Goncharova, N. Y. Prokofeva, E. S. Voroshilina and D. M. Kolpashchikov, Analyst, 2018, Accepted Manuscript , DOI: 10.1039/C8AN02274G

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