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Imaging Nucleus Viscosity and G-quadruplex DNA in Living Cells by a Nucleus-Targeting Two-Photon Fluorescent Probe

Abstract

A two-photon fluorescent probe, TP-2Bz, was designed, synthesized and exhibited good targeting capabilities toward cell nuleus. In particular, TP-2Bz demonstrated a high selectivity to both G-quadruplex DNA and viscosity inside the nucleus with significant ratiometric enhancement in fluorescence, providing a specific, versatile imaging tool for analyzing the viscosity and G-quadruplex DNA in living cells.

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Publication details

The article was received on 24 Aug 2018, accepted on 04 Oct 2018 and first published on 10 Oct 2018


Article type: Paper
DOI: 10.1039/C8AN01643G
Citation: Analyst, 2018, Accepted Manuscript
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    Imaging Nucleus Viscosity and G-quadruplex DNA in Living Cells by a Nucleus-Targeting Two-Photon Fluorescent Probe

    W. Sun, J. Cui, L. Ma, Z. Lu, B. Gong, L. He and R. Wang, Analyst, 2018, Accepted Manuscript , DOI: 10.1039/C8AN01643G

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