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Issue 23, 2018
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Imaging nucleus viscosity and G-quadruplex DNA in living cells using a nucleus-targeting two-photon fluorescent probe

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Abstract

A two-photon fluorescent probe, TP-2Bz, was designed and synthesized and it exhibited good targeting capabilities toward cell nuclei. In particular, TP-2Bz demonstrated a high selectivity to both G-quadruplex DNA and viscosity inside the nucleus with significant ratiometric enhancement in fluorescence, providing a specific, versatile imaging tool for analyzing the viscosity and G-quadruplex DNA in living cells.

Graphical abstract: Imaging nucleus viscosity and G-quadruplex DNA in living cells using a nucleus-targeting two-photon fluorescent probe

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Publication details

The article was received on 24 Aug 2018, accepted on 04 Oct 2018 and first published on 10 Oct 2018


Article type: Paper
DOI: 10.1039/C8AN01643G
Citation: Analyst, 2018,143, 5799-5804
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    Imaging nucleus viscosity and G-quadruplex DNA in living cells using a nucleus-targeting two-photon fluorescent probe

    W. Sun, J. Cui, L. Ma, Z. Lu, B. Gong, L. He and R. Wang, Analyst, 2018, 143, 5799
    DOI: 10.1039/C8AN01643G

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