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Issue 23, 2018
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“ON–OFF–ON” fluorescent probes based on nitrogen-doped carbon dots for hypochlorite and bisulfite detection in living cells

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Abstract

Although hypochlorite (ClO) and bisulfite (HSO3) play important roles in the biological immune system and the aging process of living organisms, they are also classified as a third type of carcinogens. Hence, a convenient and efficient method to monitor ClO and HSO3 in ecological environments is highly desired. In this article, an “ON–OFF–ON” fluorescent probe based on nitrogen-doped carbon dots (N-CDs) for the detection of ClO and HSO3 has been demonstrated successfully. Because of the destruction of the surface passivation layer, the fluorescence of the N-CDs was quenched by ClO. Furthermore, the quenched fluorescence of the N-CDs was restored efficiently through the increase in conjugation from the attached sulfo groups, indicating the feasibility of ClO and HSO3 detection. This fluorescent probe exhibited excellent sensitivity and selectivity to ClO and HSO3 detection with the limits of detection (LODs) of 3.4 μM and 0.27 μM in aqueous solution, respectively. In addition, the as-prepared N-CDs were successfully applied to detect both ClO and HSO3 in living cells due to their low toxicity and fast response speed.

Graphical abstract: “ON–OFF–ON” fluorescent probes based on nitrogen-doped carbon dots for hypochlorite and bisulfite detection in living cells

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Publication details

The article was received on 16 Aug 2018, accepted on 14 Oct 2018 and first published on 16 Oct 2018


Article type: Paper
DOI: 10.1039/C8AN01585F
Citation: Analyst, 2018,143, 5834-5840
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    “ON–OFF–ON” fluorescent probes based on nitrogen-doped carbon dots for hypochlorite and bisulfite detection in living cells

    R. Wang, R. Wang, D. Ju, W. Lu, C. Jiang, X. Shan, Q. Chen and G. Sun, Analyst, 2018, 143, 5834
    DOI: 10.1039/C8AN01585F

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