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Advances in mass spectrometry based single-cell metabolomics

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Abstract

Metabolomics has grown into a prominent field contributing to the molecular understanding of complex biological processes in both health and disease. Furthermore, single-cells are known to display metabolic differences between seemingly homogeneous populations of cells. Single-cell metabolomics attempts to analyze many cellular metabolites from single cells to understand phenotypic heterogeneity, which is a significant challenge due to the low analyte abundances and limited sample volumes. Label-free metabolite detection can be achieved with mass spectrometry, which is capable of simultaneously analyzing hundreds of metabolites. Herein, we review the recent advances in mass spectrometry based single-cell metabolomics, highlighting the current state-of-the-art within the last three years, and identify the challenges to move the field forward.

Graphical abstract: Advances in mass spectrometry based single-cell metabolomics

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Publication details

The article was received on 15 Aug 2018, accepted on 12 Oct 2018 and first published on 23 Oct 2018


Article type: Minireview
DOI: 10.1039/C8AN01581C
Citation: Analyst, 2018, Advance Article
  • Open access: Creative Commons BY license
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    Advances in mass spectrometry based single-cell metabolomics

    K. D. Duncan, J. Fyrestam and I. Lanekoff, Analyst, 2018, Advance Article , DOI: 10.1039/C8AN01581C

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