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A ratiometric fluorescent BODIPY-based probe for rapid and highly sensitive detection of cysteine in human plasma

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Abstract

Biological thiols, especially low molecular weight thiols, including cysteine (Cys), homocysteine (Hcy) and glutathione (GSH), play a pivotal role in physiological and pathological systems. Thus, the detection of biothiols is highly important for early diagnosis of diseases and evaluation of disease progression. Herein, we developed a highly selective and sensitive ratiometric fluorescent 8-Cl BODIPY-based probe with high fluorescence quantum yields. The probe displayed a sensitive response to Cys and Hcy over other biothiols, which can be visualized colorimetrically and/or fluorescently. The probe was successfully applied to detect Cys in human plasma, demonstrating its great value for practical application in biological sample analysis.

Graphical abstract: A ratiometric fluorescent BODIPY-based probe for rapid and highly sensitive detection of cysteine in human plasma

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Publication details

The article was received on 29 Jul 2018, accepted on 16 Sep 2018 and first published on 25 Sep 2018


Article type: Paper
DOI: 10.1039/C8AN01438H
Citation: Analyst, 2018, Advance Article
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    A ratiometric fluorescent BODIPY-based probe for rapid and highly sensitive detection of cysteine in human plasma

    N. Wang, Y. Wang, J. Gao, X. Ji, J. He, J. Zhang and W. Zhao, Analyst, 2018, Advance Article , DOI: 10.1039/C8AN01438H

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