Issue 22, 2018

Cationic polymer-based plasmonic sensor array that discriminates proteins

Abstract

Breaking the restrictions of a lock-and-key sensing strategy which relies only on the most dominant interactions between the sensing element and target, here, we develop a colorimetric sensor array with three kinds of cationic polymers (polydiallyl dimethylammonium chloride (PDDA), chitosan (CTS), and cetyltrimethylammonium bromide (CTAB)) as nonspecific receptors. Diverse interactions between cationic polymers and proteins make gold nanoparticles (Au NPs) exhibit different aggregation behaviors, resulting in changes in color and absorbance of Au NPs. Based on the diverse colorimetric response patterns, seven proteins were successfully discriminated visually at the 20 nM level by linear discrimination analysis (LDA). Furthermore, the practicability of the sensor array was validated by the successful identification of proteins without any overlap in human serum samples.

Graphical abstract: Cationic polymer-based plasmonic sensor array that discriminates proteins

Supplementary files

Article information

Article type
Paper
Submitted
20 Jul 2018
Accepted
29 Sep 2018
First published
12 Oct 2018

Analyst, 2018,143, 5578-5582

Cationic polymer-based plasmonic sensor array that discriminates proteins

H. Xi, X. Li, Q. Liu and Z. Chen, Analyst, 2018, 143, 5578 DOI: 10.1039/C8AN01360H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements