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Monitoring of pH Change in Live Rat Brain with MoS2/PAN Functionalized Microneedle


Monitoring the dynamic pH changes in vivo remains very essential to comprehend the function of pH in various physiological processes. In this study, we report a high-performance electrochemical pH microneedle based on acupuncture needle (AN) for real-time monitoring of pH changes in rat brain. The pH microneedle was prepared by a layer-to-layer assembly of molybdenum disulfide (MoS2) nanosheets and polyaniline (PAN), with an attempt to achieve highly sensitive detection of hydrogen ions (H+). The as-prepared PAN/MoS2/AN exhibited high Nernstian response of -51.2 mV/pH over a wide pH range from 3.0 to 9.0, and excellent selectivity toward pH against other potential interfering species in the brain. Moreover, the corresponding open circuit potential rapidly increased and decreased when Na2CO3 or NaH2PO4 was injected into rat brain, respectively, demonstrating that the PAN/MoS2/AN has an excellent response toward pH changes in vivo. This work provides a new potentiometric method for real-time monitoring of dynamic pH changes in vivo with high reliability and stability.

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Publication details

The article was received on 22 Jun 2018, accepted on 01 Aug 2018 and first published on 06 Aug 2018

Article type: Paper
DOI: 10.1039/C8AN01149D
Citation: Analyst, 2018, Accepted Manuscript
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    Monitoring of pH Change in Live Rat Brain with MoS2/PAN Functionalized Microneedle

    J. Zhou, F. Ding, L. Tang, T. Li, Y. Li, Y. Zhang, H. Gong, Y. Li and G. Zhang, Analyst, 2018, Accepted Manuscript , DOI: 10.1039/C8AN01149D

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