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An S-alkyl thiocarbamate-based biosensor for highly sensitive and selective detection of hypochlorous acid

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Abstract

We reported a near-infrared biosensor that features a dihydromethylene blue and an S-alkyl thiocarbamate linker to detect hypochlorous acid in a drastic fluorescence turn-on response. We achieved high sensitivity at the nanomolar level and high selectivity that resolves the interference issue with mercury ions and other transition metal ions. We demonstrated the response mechanism by analysing the released segments, and investigated the imaging capability to detect both exogenous and endogenous hypochlorous acid in living cells.

Graphical abstract: An S-alkyl thiocarbamate-based biosensor for highly sensitive and selective detection of hypochlorous acid

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Publication details

The article was received on 04 Jun 2018, accepted on 30 Jul 2018 and first published on 31 Jul 2018


Article type: Communication
DOI: 10.1039/C8AN01027G
Citation: Analyst, 2018, Advance Article
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    An S-alkyl thiocarbamate-based biosensor for highly sensitive and selective detection of hypochlorous acid

    J. Sun and F. Feng, Analyst, 2018, Advance Article , DOI: 10.1039/C8AN01027G

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