Jump to main content
Jump to site search


Rapid and sensitive detection of nodularin-R in water by a label-free BLI aptasensor

Author affiliations

Abstract

Contamination of freshwater with nodularin-R (NOD-R) represents a significant global environmental and public health concern. However, ethical problems and technical difficulties surrounding the current detection methods for NOD-R necessitate further studies to devise appropriate alternatives within a regulatory monitoring regime. In this work, we employed an aptamer as a specific recognition element and developed a biolayer interferometry (BLI) biosensor platform for NOD-R detection. The aptasensor we propose displayed a broad detection range from 40 to 600 nM NOD-R (and a linear response range from 40 to 200 nM), and achieved a detection limit as low as 167 pM. In addition, the aptamer-based biosensor was shown to possess high selectivity, as well as good reproducibility and stability. We believe that this novel aptamer-based biosensor provides a potential alternative for the sensitive and rapid detection of NOD-R.

Graphical abstract: Rapid and sensitive detection of nodularin-R in water by a label-free BLI aptasensor

Back to tab navigation

Supplementary files

Publication details

The article was received on 26 Mar 2018, accepted on 20 Jul 2018 and first published on 20 Jul 2018


Article type: Paper
DOI: 10.1039/C8AN00567B
Citation: Analyst, 2018, Advance Article
  •   Request permissions

    Rapid and sensitive detection of nodularin-R in water by a label-free BLI aptasensor

    S. Ouyang, B. Hu, R. Zhou, D. Liu, D. Peng, Z. Li, Z. Li, B. Jiao and L. Wang, Analyst, 2018, Advance Article , DOI: 10.1039/C8AN00567B

Search articles by author

Spotlight

Advertisements