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Issue 47, 2018
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Linker chemistry dictates the delivery of a phototoxic organometallic rhenium(i) complex to human cervical cancer cells from core crosslinked star polymer nanoparticles

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Abstract

We have investigated core-crosslinked star polymer nanoparticles designed with tunable release chemistries as potential nanocarriers for a photoactive Re(I) organometallic complex. The nanoparticles consisted of a brush poly(oligo-ethylene glycol)methyl ether acrylate (POEGA) corona and a cross-linked core of non-biodegradable N,N′-methylenebis(acrylamide) (MBAA) and either pentafluorophenyl acrylate (PFPA), 3-vinyl benzaldehyde (VBA) or diacetone acrylamide (DAAM). Each star was modified with an amine functionalized photodynamic agent (i.e. a rhenium(I) organometallic complex) resulting in the formation of either a stable amide bond (POEGA-star-PFPA), or hydrolytically labile aldimine (POEGA-star-VBA) or ketimine bonds (POEGA-star-DAAM). These materials revealed linker dependent photo- and cytotoxicity when tested in vitro against non-cancerous lung fibroblast MRC-5 cells and HeLa human cervical cancer cells: the toxicity results correlated with final intracellular Re concentrations.

Graphical abstract: Linker chemistry dictates the delivery of a phototoxic organometallic rhenium(i) complex to human cervical cancer cells from core crosslinked star polymer nanoparticles

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Supplementary files

Article information


Submitted
19 Sep 2018
Accepted
28 Oct 2018
First published
29 Oct 2018

J. Mater. Chem. B, 2018,6, 7805-7810
Article type
Communication

Linker chemistry dictates the delivery of a phototoxic organometallic rhenium(I) complex to human cervical cancer cells from core crosslinked star polymer nanoparticles

S. H. Yu, M. Patra, S. Ferrari, P. Ramirez Garcia, N. A. Veldhuis, L. M. Kaminskas, B. Graham, J. F. Quinn, M. R. Whittaker, G. Gasser and T. P. Davis, J. Mater. Chem. B, 2018, 6, 7805
DOI: 10.1039/C8TB02464B

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