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Issue 43, 2018
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3D printing of nanocellulose hydrogel scaffolds with tunable mechanical strength towards wound healing application

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Abstract

We present for the first time approaches to 3D-printing of nanocellulose hydrogel scaffolds based on double crosslinking, first by in situ Ca2+ crosslinking and post-printing by chemical crosslinking with 1,4-butanediol diglycidyl ether (BDDE). Scaffolds were successfully printed from 1% nanocellulose hydrogels, with their mechanical strength being tunable in the range of 3 to 8 kPa. Cell tests suggest that the 3D-printed and BDDE-crosslinked nanocellulose hydrogel scaffolds supported fibroblast cells’ proliferation, which was improving with increasing rigidity. These 3D-printed scaffolds render nanocellulose a new member of the family of promising support structures for crucial cellular processes during wound healing, regeneration and tissue repair.

Graphical abstract: 3D printing of nanocellulose hydrogel scaffolds with tunable mechanical strength towards wound healing application

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Supplementary files

Article information


Submitted
04 Jul 2018
Accepted
13 Oct 2018
First published
15 Oct 2018

J. Mater. Chem. B, 2018,6, 7066-7075
Article type
Paper

3D printing of nanocellulose hydrogel scaffolds with tunable mechanical strength towards wound healing application

C. Xu, B. Zhang Molino, X. Wang, F. Cheng, W. Xu, P. Molino, M. Bacher, D. Su, T. Rosenau, S. Willför and G. Wallace, J. Mater. Chem. B, 2018, 6, 7066
DOI: 10.1039/C8TB01757C

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