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Issue 38, 2018
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Glyoxylamide-based self-assembly hydrogels for sustained ciprofloxacin delivery

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Abstract

In this study, we report the synthesis of glyoxylamide peptide-mimics as self-assembled gels with well-defined molecular structures for topical delivery of ciprofloxacin (CIP). The glyoxylamide peptide mimics successfully formed hydrogels with critical gel concentrations of 0.02–0.08% (w/v). The mechanical strength, secondary structure, and fiber morphology of these hydrogels can be modulated by varying the N-substituent of the ring-opened isatins. The synthesised hydrogel exhibited a high loading capacity of CIP (40% (w/w)) and a sustained release profile. The CIP-loaded hydrogels were able to release CIP for more than 15 days and the released solution was shown to retain activity against Gram-positive and Gram-negative bacteria. In addition, the hydrogels formed showed low toxicity against Cos7 cells.

Graphical abstract: Glyoxylamide-based self-assembly hydrogels for sustained ciprofloxacin delivery

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Supplementary files

Article information


Submitted
16 May 2018
Accepted
21 Aug 2018
First published
28 Aug 2018

J. Mater. Chem. B, 2018,6, 6089-6098
Article type
Paper

Glyoxylamide-based self-assembly hydrogels for sustained ciprofloxacin delivery

V. R. Aldilla, A. D. Martin, S. Nizalapur, C. E. Marjo, A. M. Rich, K. K. K. Ho, L. M. Ittner, D. StC. Black, P. Thordarson and N. Kumar, J. Mater. Chem. B, 2018, 6, 6089
DOI: 10.1039/C8TB01290C

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