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Issue 24, 2018
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Room temperature synthesis of dendritic mesoporous silica nanoparticles with small sizes and enhanced mRNA delivery performance

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Abstract

Dendritic mesoporous silica nanoparticles (DMSNs) with a small diameter (∼50 nm) and a large pore size (>20 nm) have been synthesized at room temperature. It is shown that the choice of room temperature synthesis favours the formation of large-pore and small-size DMSNs compared to conventional synthesis at higher temperature. Compared to mesoporous silica nanoparticles with a similar particle size but a smaller mesopore size and DMSNs with a similar pore size but a larger particle size, DMSNs with both a small particle size and a large pore size possess a higher in vitro mRNA transfection efficiency, indicating their potential as promising delivery vehicles for exogenous genetic molecules.

Graphical abstract: Room temperature synthesis of dendritic mesoporous silica nanoparticles with small sizes and enhanced mRNA delivery performance

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Supplementary files

Article information


Submitted
27 Feb 2018
Accepted
17 May 2018
First published
17 May 2018

J. Mater. Chem. B, 2018,6, 4089-4095
Article type
Paper
Author version available

Room temperature synthesis of dendritic mesoporous silica nanoparticles with small sizes and enhanced mRNA delivery performance

Y. Wang, H. Song, M. Yu, C. Xu, Y. Liu, J. Tang, Y. Yang and C. Yu, J. Mater. Chem. B, 2018, 6, 4089
DOI: 10.1039/C8TB00544C

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