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Issue 30, 2018
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Novel iron oxide–cerium oxide core–shell nanoparticles as a potential theranostic material for ROS related inflammatory diseases

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Abstract

Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are key signaling molecules that play an important role in the inflammation and progression of many diseases such as cardiovascular disease, especially atherosclerosis. ROS are in particular a significant factor in the development of rheumatoid arthritis and other autoimmune diseases such as allergies. In this study, novel Fe3O4/CeO2 core–shell theranostic nanoparticles capable of reacting with ROS and of being detected by MRI were synthesized and thoroughly characterized. In vitro studies, such as measurement of cell uptake, magnetic resonance imaging, toxicity and ROS scavenging, were conducted. The results indicate that the novel Fe3O4/CeO2 theranostic nanoparticles are effective for scavenging ROS and show excellent magnetic resonance (MR) imaging performance. These theranostic nanomaterials, therefore, show great potential for the treatment and diagnosis of ROS-related inflammatory diseases.

Graphical abstract: Novel iron oxide–cerium oxide core–shell nanoparticles as a potential theranostic material for ROS related inflammatory diseases

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Supplementary files

Article information


Submitted
04 Jan 2018
Accepted
26 Jun 2018
First published
28 Jun 2018

J. Mater. Chem. B, 2018,6, 4937-4951
Article type
Paper
Author version available

Novel iron oxide–cerium oxide core–shell nanoparticles as a potential theranostic material for ROS related inflammatory diseases

Y. Wu, Y. Yang, W. Zhao, Z. P. Xu, P. J. Little, A. K. Whittaker, R. Zhang and H. T. Ta, J. Mater. Chem. B, 2018, 6, 4937
DOI: 10.1039/C8TB00022K

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