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Issue 19, 2018
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From jamming to collective cell migration through a boundary induced transition

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Abstract

Cell monolayers provide an interesting example of active matter, exhibiting a phase transition from flowing to jammed states as they age. Here we report experiments and numerical simulations illustrating how a jammed cellular layer rapidly reverts to a flowing state after a wound. Quantitative comparison between experiments and simulations shows that cells change their self-propulsion and alignment strength so that the system crosses a phase transition line, which we characterize by finite-size scaling in an active particle model. This wound-induced unjamming transition is found to occur generically in epithelial, endothelial and cancer cells.

Graphical abstract: From jamming to collective cell migration through a boundary induced transition

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Article information


Submitted
17 Jan 2018
Accepted
20 Apr 2018
First published
01 May 2018

Soft Matter, 2018,14, 3774-3782
Article type
Paper

From jamming to collective cell migration through a boundary induced transition

O. Chepizhko, M. C. Lionetti, C. Malinverno, C. Giampietro, G. Scita, S. Zapperi and C. A. M. La Porta, Soft Matter, 2018, 14, 3774
DOI: 10.1039/C8SM00128F

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