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Issue 37, 2018
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Direct evidence for heme-assisted solid-state electronic conduction in multi-heme c-type cytochromes

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Abstract

Multi-heme cytochrome c (Cytc) proteins are key for transferring electrons out of cells, to enable intracellular oxidation to proceed in the absence of O2. In these proteins most of the hemes are arranged in a linear array suggesting a facile path for electronic conduction. To test this, we studied solvent-free electron transport across two multi-heme Cytc-type proteins: MtrF (deca-heme Cytc) and STC (tetra-heme Cytc). Transport is measured across monolayers of these proteins in a solid state configuration between Au electrodes. Both proteins showed 1000× higher conductance than single heme, or heme-free proteins, but similar conductance to monolayers of conjugated organics. Conductance is found to be temperature-independent (320–80 K), suggesting tunneling as the transport mechanism. This mechanism is consistent with IV curves modelling, results of which could be interpreted by having protein-electrode coupling as rate limiting, rather than transport within the proteins.

Graphical abstract: Direct evidence for heme-assisted solid-state electronic conduction in multi-heme c-type cytochromes

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Supplementary files

Article information


Submitted
15 Apr 2018
Accepted
26 Jul 2018
First published
27 Jul 2018

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2018,9, 7304-7310
Article type
Edge Article

Direct evidence for heme-assisted solid-state electronic conduction in multi-heme c-type cytochromes

K. Garg, M. Ghosh, T. Eliash, J. H. van Wonderen, Julea N. Butt, L. Shi, X. Jiang, F. Zdenek, J. Blumberger, I. Pecht, M. Sheves and D. Cahen, Chem. Sci., 2018, 9, 7304
DOI: 10.1039/C8SC01716F

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