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Issue 9, 2018
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Tailoring the morphology of AIEgen fluorescent nanoparticles for optimal cellular uptake and imaging efficacy

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Abstract

The rational design of robust fluorescent organic materials for long-term cell tracing is still challenging, and aggregation-caused quenching of emission is a big limitation of this strategy. Organic dyes with aggregation-induced emission (AIE) can effectively address this problem. Herein, AIEgen-containing nanoparticles, with different morphologies and emission, were prepared by assembling amphiphilic copolymers with an AIEgen. We compared the physical and chemical properties of rod-like and spherical nanoparticles, particularly investigating the effects of the shape on internalization and the imaging effect. The formulated nanoparticles exhibit advantageous features, such as a large Stokes shift, robust stability in physiological conditions, strong fluorescent emission, and photobleaching resistance. Interestingly, the rod-like nanoparticles were internalized more efficiently than their spherical counterparts, and their strong green fluorescence can still be clearly observed even after 15 days in vitro and in vivo. This work demonstrates the great potential of regulating the morphology of nanoparticles to obtain an ideal biological function.

Graphical abstract: Tailoring the morphology of AIEgen fluorescent nanoparticles for optimal cellular uptake and imaging efficacy

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Supplementary files

Article information


Submitted
02 Dec 2017
Accepted
15 Jan 2018
First published
17 Jan 2018

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2018,9, 2620-2627
Article type
Edge Article

Tailoring the morphology of AIEgen fluorescent nanoparticles for optimal cellular uptake and imaging efficacy

J. Zhang, B. Xu, W. Tian and Z. Xie, Chem. Sci., 2018, 9, 2620
DOI: 10.1039/C7SC05130A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

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    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
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    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
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    [Original citation] - Published by The Royal Society of Chemistry.

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