Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 3, 2018
Previous Article Next Article

Direct sulfonylation of anilines mediated by visible light

Author affiliations

Abstract

Sulfones feature prominently in biologically active molecules and are key functional groups for organic synthesis. We report a mild, photoredox-catalyzed reaction for sulfonylation of aniline derivatives with sulfinate salts, and demonstrate the utility of the method by the late-stage functionalization of drugs. Key features of the method are the straightforward generation of sulfonyl radicals from bench-stable sulfinate salts and the use of simple aniline derivatives as convenient readily available coupling partners.

Graphical abstract: Direct sulfonylation of anilines mediated by visible light

Back to tab navigation

Supplementary files

Article information


Submitted
05 Sep 2017
Accepted
07 Nov 2017
First published
16 Nov 2017

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2018,9, 629-633
Article type
Edge Article

Direct sulfonylation of anilines mediated by visible light

T. C. Johnson, Bryony L. Elbert, A. J. M. Farley, T. W. Gorman, C. Genicot, B. Lallemand, P. Pasau, J. Flasz, J. L. Castro, M. MacCoss, D. J. Dixon, R. S. Paton, C. J. Schofield, M. D. Smith and M. C. Willis, Chem. Sci., 2018, 9, 629
DOI: 10.1039/C7SC03891G

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

Reproduced material should be attributed as follows:

  • For reproduction of material from NJC:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
  • For reproduction of material from PCCP:
    [Original citation] - Published by the PCCP Owner Societies.
  • For reproduction of material from PPS:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
  • For reproduction of material from all other RSC journals:
    [Original citation] - Published by The Royal Society of Chemistry.

Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.


Social activity

Search articles by author

Spotlight

Advertisements