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Issue 40, 2018, Issue in Progress

Injectable alendronate-functionalized GelMA hydrogels for mineralization and osteogenesis

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Abstract

In a minimally invasive procedure, hydrogels can be injected into an affected area for drug loading and tissue repair. Here, gelatin methacryloyl (GelMA) was modified with alendronate (ALN), and three different alendronate-functionalized GelMA (GelMA-ALN) hydrogels were prepared. The modification greatly improved the swelling ratio, protein adsorption and mineralization. The GelMA-ALN hydrogels significantly promoted the in vitro osteogenic differentiation of hFOB cells as indicated by their higher alkaline phosphatase (ALP) activity, denser mineralization and up-regulated osteogenesis-related genes at both the mRNA and protein levels. Meanwhile, the cells maintained their activity and differentiated into osteoblasts when encapsulated in the GelMA-ALN hydrogels. Alendronate-modified hydrogels have potential for use in the minimally invasive treatment of irregular bone defects.

Graphical abstract: Injectable alendronate-functionalized GelMA hydrogels for mineralization and osteogenesis

Supplementary files

Article information


Submitted
25 Apr 2018
Accepted
11 Jun 2018
First published
20 Jun 2018

This article is Open Access

RSC Adv., 2018,8, 22764-22776
Article type
Paper

Injectable alendronate-functionalized GelMA hydrogels for mineralization and osteogenesis

L. Liu, X. Li, X. Shi and Y. Wang, RSC Adv., 2018, 8, 22764 DOI: 10.1039/C8RA03550D

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