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Issue 18, 2018, Issue in Progress
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Preparation and characterization of an electrospun colon-specific delivery system for salmon calcitonin

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Abstract

A novel electrospun colon-specific delivery system for salmon calcitonin (SCT) was developed to improve its stability and bioavailability. Firstly, the pectin-coated SCT liposomes were prepared by film dispersion method and then a liposomes/sodium alginate/polyvinyl alcohol fiber mat was fabricated by electrospining. Scanning electron microscopy analysis indicated that the obtained nanofibers were uniform and smooth with an average diameter of about 350 nm. The release of SCT in different simulated digestive fluids was studied and corresponding release kinetics models were built. It was found that the fiber mat containing pectin-coated SCT liposomes had better stability and colon-specific properties compared with that containing uncoated SCT liposomes and the release of SCT in the colon followed the case II transport mechanism. In addition, there is no significant change in the bioactivity of released SCT measured by ELISA. This study shows that the electrospun colon-specific fiber mat is a potential delivery system for bioactive peptides.

Graphical abstract: Preparation and characterization of an electrospun colon-specific delivery system for salmon calcitonin

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Publication details

The article was received on 13 Jan 2018, accepted on 03 Mar 2018 and first published on 08 Mar 2018


Article type: Paper
DOI: 10.1039/C8RA00385H
RSC Adv., 2018,8, 9762-9769
  • Open access: Creative Commons BY-NC license
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    Preparation and characterization of an electrospun colon-specific delivery system for salmon calcitonin

    C. Li, Y. Wei, P. Wen, K. Feng, M. Zong and H. Wu, RSC Adv., 2018, 8, 9762
    DOI: 10.1039/C8RA00385H

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