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Issue 70, 2018, Issue in Progress
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Interactions of a paracyclophane-based conjugated oligoelectrolyte with biological membranes

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Abstract

A three-dimensional conjugated oligoelectrolyte (COE) bearing a [2.2]paracyclophane unit (COE2-3-pCp) was synthesized. Its biological activity was determined both in vivo and in silico within the context of membrane perturbation and biocompatibility. Molecular dynamics simulations indicate that, compared to its linear analog (COE2-3C), COE2-3-pCp introduces more lipid disorder with higher extent of membrane thinning. COE2-3-pCp also exhibits a higher MIC towards E. coli K12 and yeast, while maintaining similar levels of membrane permeabilization. These findings suggest a new design of COEs as biocompatible cell permeabilizers.

Graphical abstract: Interactions of a paracyclophane-based conjugated oligoelectrolyte with biological membranes

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Publication details

The article was received on 28 Sep 2018, accepted on 14 Nov 2018 and first published on 29 Nov 2018


Article type: Paper
DOI: 10.1039/C8RA08069K
RSC Adv., 2018,8, 39849-39853
  • Open access: Creative Commons BY-NC license
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    Interactions of a paracyclophane-based conjugated oligoelectrolyte with biological membranes

    J. Limwongyut, Y. Liu, G. S. Chilambi, T. Seviour, J. Hinks, Y. Mu and G. C. Bazan, RSC Adv., 2018, 8, 39849
    DOI: 10.1039/C8RA08069K

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