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Issue 39, 2018, Issue in Progress
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Expanding the synthesizable multisubstituted benzo[b]thiophenes via 6,7-thienobenzynes generated from o-silylaryl triflate-type precursors

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Abstract

Various 2,3-disubstituted 6,7-thienobenzynes have been efficiently generated from the corresponding o-silylaryl triflate-type precursors by activation with fluoride ions. The method has expanded the scope of synthesizable multisubstituted benzothiophenes, including those with various heteroatom substituents, and can be applied to the synthesis of EP4 antagonist analogs.

Graphical abstract: Expanding the synthesizable multisubstituted benzo[b]thiophenes via 6,7-thienobenzynes generated from o-silylaryl triflate-type precursors

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Publication details

The article was received on 11 May 2018, accepted on 06 Jun 2018 and first published on 13 Jun 2018


Article type: Paper
DOI: 10.1039/C8RA04035D
RSC Adv., 2018,8, 21754-21758
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    Expanding the synthesizable multisubstituted benzo[b]thiophenes via 6,7-thienobenzynes generated from o-silylaryl triflate-type precursors

    S. Yoshida, T. Kuribara, T. Morita, T. Matsuzawa, K. Morimoto, T. Kobayashi and T. Hosoya, RSC Adv., 2018, 8, 21754
    DOI: 10.1039/C8RA04035D

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