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Issue 38, 2018
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A practically simple, catalyst free and scalable synthesis of N-substituted ureas in water

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Abstract

A practically simple, mild and efficient method is developed for the synthesis of N-substituted ureas by nucleophilic addition of amines to potassium isocyanate in water without organic co-solvent. Using this methodology, a variety of N-substituted ureas (mono-, di- and cyclic-) were synthesized in good to excellent yields with high chemical purity by applying simple filtration or routine extraction procedures avoiding silica gel purification. The developed methodology was also found to be suitable for gram scale synthesis of molecules having commercial application in large volumes. The identified reaction conditions were found to promote a unique substrate selectivity from a mixture of two amines.

Graphical abstract: A practically simple, catalyst free and scalable synthesis of N-substituted ureas in water

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Article information


Submitted
02 May 2018
Accepted
03 Jun 2018
First published
13 Jun 2018

This article is Open Access

RSC Adv., 2018,8, 21585-21595
Article type
Paper

A practically simple, catalyst free and scalable synthesis of N-substituted ureas in water

L. Tiwari, V. Kumar, B. Kumar and D. Mahajan, RSC Adv., 2018, 8, 21585
DOI: 10.1039/C8RA03761B

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    [Original citation] - Published by The Royal Society of Chemistry.

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