Issue 39, 2018, Issue in Progress

Copper-catalyzed tandem reaction of 2-alkynylanilines with benzoquinones: efficient access to 3-indolylquinones

Abstract

A simple, mild, catalytic and efficient method for the straightforward synthesis of an interesting class of 2-aryl/alkyl-substituted-3-indolyl quinones in good to high yields is reported for the first time. This atom-efficient method proceeds via copper-catalyzed one-pot sequential intramolecular hydroamination (C–N bond formation) of 2-alkynylanilines followed by oxidative C–C coupling with benzoquinones.

Graphical abstract: Copper-catalyzed tandem reaction of 2-alkynylanilines with benzoquinones: efficient access to 3-indolylquinones

Supplementary files

Article information

Article type
Paper
Submitted
30 Apr 2018
Accepted
04 Jun 2018
First published
15 Jun 2018
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2018,8, 22122-22126

Copper-catalyzed tandem reaction of 2-alkynylanilines with benzoquinones: efficient access to 3-indolylquinones

R. Jillella and C. H. Oh, RSC Adv., 2018, 8, 22122 DOI: 10.1039/C8RA03712D

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