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Issue 35, 2018
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Combining transition metals and transient directing groups for C–H functionalizations

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Abstract

In the domain of synthetic chemistry, C–H bond activation has always remained in the spotlight for researchers over the last few decades. Although different strategies have been employed to chemically trigger unactivated C–H bonds, transition metal catalyzed directing group (DG) aided C–H bond activation is the most explored pathway of all because of its ability to perform diverse site selective functional metamorphosis. Despite its popularity, tedious synthetic methodology requiring additional steps for the installation and removal of DGs from the target substrate diminishes its efficacy. However, replacement of directing groups by transient directing groups (tDGs) reduces the hurdle to a greater extent without compromising the product yield and selectivity. In this report we have depicted the intense journey of transient directing groups with three (Rh, Ru, and Pd) prevalent second row transition metals.

Graphical abstract: Combining transition metals and transient directing groups for C–H functionalizations

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Article information


Submitted
15 Apr 2018
Accepted
14 May 2018
First published
29 May 2018

This article is Open Access

RSC Adv., 2018,8, 19456-19464
Article type
Review Article

Combining transition metals and transient directing groups for C–H functionalizations

T. Bhattacharya, S. Pimparkar and D. Maiti, RSC Adv., 2018, 8, 19456
DOI: 10.1039/C8RA03230K

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material and it is not used for commercial purposes.

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    [Original citation] - Published by The Royal Society of Chemistry.

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